DAMUTA documentation

DAMUTA is a hierarchical Bayesian probabilistic model that separates DNA damage and misrepair processes.

Key Capabilities:

• Damage-Misrepair Separation: Infers distinct signatures for DNA damage processes and repair mechanisms

• Hierarchical Modeling: Captures sample-specific interactions and tissue-type effects

• Pan-Cancer Analysis: DAMUTA signatures estimated from 18,974 whole genome sequencing samples across 23 cancer types

• Biological Insights: Reveals tissue-specificity patterns and DNA damage response deficiencies

• Compact Representation: Resolves redundancies in current signature models

DAMUTA requires only mutation type counts to begin analysis. You can optionally provide:

• Custom signature definitions (damage and misrepair signatures)

• Hierarchical sample groupings for enhanced tissue-specific modeling

Get started

• Installation
• Quickstart
• Tutorials

Indices and tables

• Index

• Module Index

• Search Page